Self-assembled composite microparticles with surface protrudent porphyrin nanoparticles enhance cellular uptake and photodynamic therapy,Materials Horizons

当前位置： X-MOL 学术 › Mater. Horiz. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Self-assembled composite microparticles with surface protrudent porphyrin nanoparticles enhance cellular uptake and photodynamic therapy
Materials Horizons ( IF 12.2 ) Pub Date : 2017-09-22 00:00:00 , DOI: 10.1039/c7mh00420f
Wenbo Zhang _{1,

2,

3} , Huiying Li _{1,

2,

3} , Ying Qin _{1,

2,

3} , Changyou Gao _{1,

2,

3,

3,

4}

Affiliation

The surface topology of nano/microparticles plays a significant role in modulating their interactions with cells, and may serve as a robust strategy for promoting cellular delivery. However, it is still an on-going challenge to achieve enhanced cellular delivery using surface-engineered organic-based particles. Herein, novel porphyrin micro–nanocomposite particles (MP–NPs), with poly(allylamine hydrochloride)-g-porphyrin MPs (PAH-g-Por MPs) as the core and porphyrin NPs as the protrudent structures on the surface, were prepared through a pH-responsive partial decomposition-induced self-assembly method. The porphyrin domains were less aggregated and easily exposed to cells, leading to significantly enhanced cellular uptake, stronger generation of intracellular reactive oxygen species (ROS), and a more effective photodynamic therapy effect compared with their smooth counterpart microparticles (MPs). The novel concept of turning therapeutics into biomimetic nanomaterials for enhanced cellular delivery and therapy may provide an inspiring horizon for the design of photosensitizers or other therapeutic delivery systems.

中文翻译：

具有表面突出的卟啉纳米颗粒的自组装复合微粒可增强细胞摄取和光动力疗法

纳米/微粒的表面拓扑在调节其与细胞的相互作用中起着重要作用，并且可以作为促进细胞递送的可靠策略。然而，使用表面工程有机基颗粒实现增强的细胞递送仍然是一个持续的挑战。在这里，新型的卟啉微-纳米复合颗粒（MP-NPs），与聚（盐酸烯丙胺）-g-卟啉MPs（PAH- g-Por MPs为核心，卟啉NPs为表面上的突出结构，是通过pH响应部分分解诱导的自组装方法制备的。卟啉结构域聚集少且易于暴露于细胞，与光滑的对应微粒（MPs）相比，可显着增强细胞摄取，增强细胞内活性氧（ROS）的生成，并具有更有效的光动力治疗效果。将治疗剂转变为仿生纳米材料以增强细胞递送和治疗的新颖概念可能为光敏剂或其他治疗剂递送系统的设计提供启发。

更新日期：2017-10-02

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11