Pro‐Regenerative Hydrogel Restores Scarless Skin during Cutaneous Wound Healing,Advanced Healthcare Materials

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Pro‐Regenerative Hydrogel Restores Scarless Skin during Cutaneous Wound Healing
Advanced Healthcare Materials ( IF 10.0 ) Pub Date : 2017-09-25 , DOI: 10.1002/adhm.201700659
Guoming Sun ₁

Affiliation

The transformation of fibrotic healing process to regenerative one has great potential to fully restore wounded skin. The M2 macrophage phenotype promotes constructive tissue remodeling and instructs tissue repair in a regenerative manner. It is hypothesized that hydrogels that can establish robustness of endogenous cells to regulate M2 phenotype will promote constructive dermal remodeling. Toward this end, a series of dextran‐based bioabsorbable hydrogels are developed and self‐crosslinkable dextran‐isocyanatoethyl methacrylate‐ethylamine (DexIEME) is identified as the potential scaffold. The initial screening study revealed that DexIEME has superior biocompatibility in varying concentrations. Although DexIEME brings about low proinflammatory responses, it promotes M2 macrophage phenotype. Then the optimized hydrogel formulation is tested for acute skin injuries using both murine and porcine models. Preliminary data demonstrated that the innovative DexIEME hydrogel promotes complete skin regeneration with hair regrowth on pre‐existing scars, while untreated scars remain intact. Preclinical studies further demonstrated that the DexIEME hydrogel regenerated perfect skin during deep porcine wound healing. Overall, the approach to investigate immune‐modulated hydrogels yields pro‐regenerative DexIEME hydrogel, which may lead to greater clinical success in treating deep dermal injury and attenuating scar formation.

中文翻译：

前再生水凝胶可在皮肤伤口愈合期间恢复无疤的皮肤

纤维化愈合过程向再生过程的转化具有完全恢复受伤皮肤的巨大潜力。M2巨噬细胞表型促进建设性组织重塑，并以再生方式指示组织修复。假设可以建立内源性细胞的健壮性来调节M2表型的水凝胶将促进建设性的皮肤重塑。为此，开发了一系列基于右旋糖酐的生物可吸收水凝胶，并确定了可自交联的右旋糖酐-异氰酸根合甲基丙烯酸乙酯-乙胺（DexIEME）是潜在的支架。初步筛选研究表明，DexIEME在不同浓度下均具有出色的生物相容性。尽管DexIEME引起了较低的促炎反应，但它促进了M2巨噬细胞表型。然后，使用鼠和猪模型对优化的水凝胶制剂进行急性皮肤损伤测试。初步数据表明，创新的DexIEME水凝胶可在原有疤痕上使头发再生长，从而促进完整的皮肤再生，而未处理的疤痕则完好无损。临床前研究进一步证明，DexIEME水凝胶可在深层猪伤口愈合过程中再生出完美的皮肤。总体而言，研究免疫调节水凝胶的方法可产生再生前的DexIEME水凝胶，这可能会在治疗深层皮肤损伤和减轻疤痕形成方面取得更大的临床成功。而未经治疗的疤痕则完好无损。临床前研究进一步证明，DexIEME水凝胶可在深层猪伤口愈合过程中再生出完美的皮肤。总体而言，研究免疫调节水凝胶的方法可产生再生前的DexIEME水凝胶，这可能会在治疗深层皮肤损伤和减轻疤痕形成方面取得更大的临床成功。而未经治疗的疤痕则完好无损。临床前研究进一步证明，DexIEME水凝胶可在深层猪伤口愈合过程中再生出完美的皮肤。总体而言，研究免疫调节水凝胶的方法可产生再生前的DexIEME水凝胶，这可能会在治疗深层皮肤损伤和减轻疤痕形成方面取得更大的临床成功。

更新日期：2017-09-25

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