The adult organism is characterized by remarkable plasticity, which enables efficient regeneration and restoration of homeostasis after damage. When aberrantly activated, this plasticity contributes to tumour initiation and progression. Here we review recent advances in this field with a focus on cell fate changes and the epithelial–mesenchymal transition—two distinct, yet closely related, forms of plasticity with fundamental roles in homeostasis and cancer.

中文翻译：

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上皮稳态和肿瘤发生中的细胞可塑性

成年生物的特点是具有显着的可塑性，可在受损后有效地再生和恢复体内稳态。当异常激活时，这种可塑性有助于肿瘤的发生和发展。在这里，我们回顾该领域的最新进展，重点是细胞命运的变化以及上皮-间质转化-这两种截然不同但密切相关的可塑性形式，在体内稳态和癌症中起着基本作用。