Cancer cells preferentially metastasize to certain organs. A study in mouse models of breast cancer shows that the DKK1 negative regulator of WNT signalling inhibits tropism to the lung, but enhances tropism to the bone due to the differential regulation of canonical and non-canonical WNT signalling in the two microenvironments.

中文翻译：

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什么 DKK 确定转移的位置。

癌细胞优先转移到某些器官。一项针对乳腺癌小鼠模型的研究表明，WNT 信号传导的 DKK1 负调节因子抑制了向肺的趋向性，但由于两种微环境中经典和非经典 WNT 信号传导的差异调节，增强了对骨的趋向性。