The cytokine tumour necrosis factor (TNF) and the toll-like receptors (TLRs) coordinate immune responses by activating inflammatory transcriptional programs, but these signals can also trigger cell death. Recent studies identify the MAP kinase substrate MK2 as a key player in determining whether cells live or die in response to TNF and TLR signalling.

中文翻译：

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MK2平衡炎症和细胞死亡。

细胞因子肿瘤坏死因子（TNF）和Toll样受体（TLR）通过激活炎症转录程序来协调免疫反应，但这些信号也可能触发细胞死亡。最近的研究表明，MAP激酶底物MK2是确定细胞是否响应TNF和TLR信号而存活或死亡的关键因素。