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Ecological Roles and Biological Activities of Specialized Metabolites from the Genus Nicotiana
Chemical Reviews ( IF 51.4 ) Pub Date : 2017-09-29 00:00:00 , DOI: 10.1021/acs.chemrev.7b00001
Amir Reza Jassbi , Somayeh Zare , Mojtaba Asadollahi , Meredith C Schuman 1, 2
Affiliation  

Species of Nicotiana grow naturally in different parts of the world and have long been used both medicinally and recreationally by human societies. More recently in our history, Nicotiana tabacum has attracted interest as one of the most economically important industrial crops. Nicotiana species are frequently investigated for their bioactive natural products, and the ecological role of their specialized metabolites in responses to abiotic stress or biotic stress factors like pathogens and herbivores. The interest of tobacco companies in genetic information as well as the success of a few wild tobacco species as experimental model organisms have resulted in growing knowledge about the molecular biology and ecology of these plants and functional studies of the plant’s natural products. Although a large number of reviews and books on biologically active natural products already exists, mostly from N. tabacum, we focus our attention on the ecological roles and biological activity of natural products, versus products from cured and processed material, in this Review. The studied compounds include alkaloids, aromatic compounds, flavonoids, volatiles, sesquiterpenoids, diterpenes alcohols, and sugar esters from trichomes of the plants, and recently characterized acyclic hydroxygeranyllinalool diterpene glycosides (HGL-DTGs). In this Review (1800s–2017), we describe the above-mentioned classes of natural products, emphasizing their biological activities and functions as they have been determined either in bioassay-guided purification approaches or in bioassays with plants in which the expression of specific biosynthetic genes has been genetically manipulated. Additionally, a review on the history, taxonomy, ecology, and medicinal application of different Nicotiana species growing around the globe presented in this Review may be of interest for pharmacognosists, natural products, and ecological chemists.

中文翻译:


烟草属特殊代谢物的生态作用和生物活性



烟草物种在世界不同地区自然生长,长期以来一直被人类社会用于药用和娱乐。最近,在我们的历史上,烟草作为经济上最重要的经济作物之一引起了人们的兴趣。人们经常研究烟草物种的生物活性天然产物,以及其专门代谢物在响应非生物胁迫或生物胁迫因素(如病原体和食草动物)中的生态作用。烟草公司对遗传信息的兴趣以及一些野生烟草物种作为实验模式生物的成功,导致人们对这些植物的分子生物学和生态学以及植物天然产物的功能研究的了解不断增长。尽管已经存在大量关于生物活性天然产品的评论和书籍,其中大部分来自烟草,但在这篇评论中,我们将注意力集中在天然产品的生态作用和生物活性上,而不是来自固化和加工材料的产品。研究的化合物包括生物碱、芳香族化合物、类黄酮、挥发物、倍半萜类化合物、二萜醇和植物毛状体的糖酯,以及最近表征的无环羟基香叶醛二萜糖苷(HGL-DTG)。在这篇综述(1800-2017)中,我们描述了上述类别的天然产物,强调了它们的生物活性和功能,因为它们已经在生物测定指导的纯化方法或植物生物测定中确定,其中特定生物合成的表达基因已被基因操纵。 此外,本综述对全球不同烟草品种的历史、分类学、生态学和药物应用进行了综述,可能会引起生药学家、天然产物和生态化学家的兴趣。
更新日期:2017-09-29
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