The mechanisms by which 3D chromatin looping interactions mediate cell type-specific gene expression are an active area of investigation. In this issue of Molecular Cell, Phanstiel et al. (2017) annotate five classes of loops during macrophage development and predict candidate factors involved in their regulation.

中文翻译：

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动态循环交互：为巨噬细胞设置3D舞台

3D染色质环相互作用介导细胞类型特异性基因表达的机制是一个活跃的研究领域。在本期《分子细胞》中，Phanstiel等人。（2017）注释了巨噬细胞发育过程中的五类循环，并预测了参与其调控的候选因子。