Silica-Immobilized NHC-Gold(I) Complexes: Versatile Catalysts for the Functionalization of Alkynes under Batch and Continuous Flow Conditions,ACS Catalysis

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Silica-Immobilized NHC-Gold(I) Complexes: Versatile Catalysts for the Functionalization of Alkynes under Batch and Continuous Flow Conditions
ACS Catalysis ( IF 11.3 ) Pub Date : 2017-09-25 00:00:00 , DOI: 10.1021/acscatal.7b02142
Jeymy T. Sarmiento ₁ , Samuel Suárez-Pantiga ₁ , Andrea Olmos ₁ , Teresa Varea ₁ , Gregorio Asensio ₁

Affiliation

Immobilized sterically demanding NHC-Au(I) complexes silica-[(IPr_R)Au]Cl and silica-[(IAdPr_R)Au]Cl are synthesized and characterized. These complexes are suitable catalysts in typical homogeneous Au(I)-catalyzed alkyne reactions such as hydration, hydroamination, hydroarylation, or cycloisomerization. The results obtained with the immobilized catalysts in reactions in batch are comparable to those obtained with their homogeneous counterparts with the advantage of easily recovered and recycled in successive reactions. Their catalytic activity decreases when reused in batch reactions, probably because of crushing that is associated with magnetic stirring. In contrast, these immobilized catalysts are very effective when used under continuous flow conditions in which the same cartridge can be used to catalyze different types of reaction successively for a long period without any noticeable loss of activity.

中文翻译：

硅胶固定的NHC-Gold（I）配合物：用于间歇和连续流动条件下炔烃功能化的多功能催化剂

固定空间要求的NHC-Au（I）配合物二氧化硅-[（IPr _R）Au] Cl和二氧化硅-[（IAdPr _R合成并表征）这些络合物在典型的均相Au（I）催化的炔烃反应（例如水合，加氢胺化，加氢芳基化或环异构化）中是合适的催化剂。用固定的催化剂分批反应获得的结果与用它们的均相对应物获得的结果相当，其优点是易于在后续反应中回收和再循环。当重新用于批处理反应中时，它们的催化活性降低，这可能是由于与磁力搅拌相关的压碎。相反，这些固定化的催化剂在连续流动条件下使用时非常有效，在连续流动条件下，相同的滤芯可以长时间连续地连续催化不同类型的反应，而活性没有任何明显的损失。

更新日期：2017-09-25

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