Quantitative analysis of salvianolic acids, ginsenosides and borneols using 1H qNMR for quality control of compound Danshen dripping pills,Analytical Methods

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Quantitative analysis of salvianolic acids, ginsenosides and borneols using 1H qNMR for quality control of compound Danshen dripping pills
Analytical Methods ( IF 2.7 ) Pub Date : 2017-08-17 00:00:00 , DOI: 10.1039/c7ay00938k
Xialin Chen _{1,

2,

3,

4} , Jin Qi _{1,

2,

3,

4,

5} , Boyang Yu _{1,

2,

3,

4,

5}

Affiliation

Compound Danshen Dripping Pills (CDDPs) are a Chinese herbal medicinal preparation composed of Salviae miltiorrhizae Radix and two other Chinese medicines, Notoginseng Radix and Borneolum. The main components of CDDPs are protocatechuic aldehyde, danshensu, salvianolic acid A, rosmarinic acid, ginsenoside Rg₁, ginsenoside Rb₁, L-(−)-borneol and isoborneol. The complex composition of CDDPs, which contains phenolic acids, ginseng saponins and borneols, makes quantitative analysis by traditional methods difficult. Therefore, a fast and accurate ¹H qNMR method was established that can simultaneously determine the eight main components of CDDPs. The qNMR method was well validated and successfully applied in the determination of ten sample batches. The vector cosine angle method was used for further analysis of the results to evaluate the sample quality. The results indicate that the qNMR method is suitable for the quality control of CDDPs and has potential as an easy alternative for the analysis of other complex Traditional Chinese Medicines (TCMs) that require two or more traditional instruments for comprehensive quantitative analysis.

中文翻译：

使用¹ H qNMR定量分析丹参中的丹酚酸，人参皂甙和冰片，以控制复方丹参滴丸的质量

复方丹参滴丸（CDDPs）是一种中草药制剂，由丹参和其他两种中药三七和冰片组成。CDDP的主要成分是原儿茶醛，丹参素，丹酚酸A，迷迭香酸，人参皂苷Rg ₁，人参皂苷Rb ₁，L -（-）-冰片醇和异冰片醇。CDDP的复杂成分包含酚酸，人参皂苷和冰片，因此很难通过传统方法进行定量分析。因此，快速准确¹建立了可以同时测定CDDP八个主要成分的1q NMR方法。qNMR方法已得到充分验证，并成功应用于十批样品的测定中。矢量余弦角法用于结果的进一步分析，以评估样品质量。结果表明，qNMR方法适用于CDDP的质量控制，具有潜在的简便替代方法，可用于分析需要两种或更多种传统仪器进行全面定量分析的其他复杂中药（TCM）。

更新日期：2017-09-25

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