A fast, reconfigurable flow switch for paper microfluidics based on selective wetting of folded paper actuator strips,Lab on a Chip

当前位置： X-MOL 学术 › Lab Chip › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

A fast, reconfigurable flow switch for paper microfluidics based on selective wetting of folded paper actuator strips
Lab on a Chip ( IF 6.1 ) Pub Date : 2017-09-19 00:00:00 , DOI: 10.1039/c7lc00620a
Taejoon Kong _{1,

2,

3,

4} , Shawn Flanigan _{2,

3,

4,

5} , Matthew Weinstein _{1,

2,

3,

4} , Upender Kalwa _{1,

2,

3,

4} , Christopher Legner _{1,

2,

3,

4} , Santosh Pandey _{1,

2,

3,

4}

Affiliation

In paper microfluidics, the development of smart and versatile switches is critical for the regulation of fluid flow across multiple channels. Past approaches in creating switches are limited by long response times, large actuation fluid volumes, and use of external control circuitry. We seek to mitigate these difficulties through the development of a unique actuator device made entirely out of chromatography paper and incorporated with folds. Selective wetting of the fold with an actuation fluid, either at the crest or trough, serves to raise or lower the actuator's tip and thus engage or break the fluidic contact between channels. Here the actuator's response time is dramatically reduced (within two seconds from wetting) and a very small volume of actuation fluid is consumed (four microliters). Using this actuation principle, we implement six switch configurations which can be grouped as single-pole single-throw (normally OFF and normally ON) and single-pole double-throw (with single and double break). By employing six actuators in parallel, an autonomous colorimetric assay is built to detect the presence of three analytes − glucose, protein, and nitrite − in artificial saliva. Finally, this work brings the concept of origami to paper microfluidics where multiple-fold geometries can be exploited for programmable switching of fluidic connections.

中文翻译：

快速，可重新配置的纸微流控流量开关，基于对折纸驱动器条的选择性润湿

在纸质微流体中，智能多功能开关的开发对于调节跨多个通道的流体流量至关重要。过去创建开关的方法受到响应时间长，致动流体量大以及使用外部控制电路的限制。我们寻求通过开发一种完全由色谱纸制成并与褶皱结合在一起的独特致动器装置来减轻这些困难。在顶部或谷部用致动流体对折痕的选择性润湿用于升高或降低致动器的尖端，从而接合或破坏通道之间的流体接触。在此，执行器的响应时间大大缩短（从润湿起两秒钟之内），消耗的驱动液量非常小（四微升）。利用这种驱动原理，我们实现了六个开关配置，这些配置可以分为单刀单掷（常闭和常开）和单刀双掷（单断和双断）。通过并行使用六个执行器，可以建立自主的比色测定法，以检测人造唾液中三种分析物的存在，即葡萄糖，蛋白质和亚硝酸盐。最后，这项工作将折纸的概念引入了纸微流体技术中，其中可以利用多种几何形状来进行流体连接的可编程切换。和亚硝酸盐-人工唾液中。最后，这项工作将折纸的概念引入了纸微流体技术中，其中可以利用多种几何形状来进行流体连接的可编程切换。和亚硝酸盐-人工唾液中。最后，这项工作将折纸的概念引入了纸微流体技术中，其中可以利用多种几何形状来进行流体连接的可编程切换。

更新日期：2017-09-25

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11