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Titanium nanoparticles (TiO2)/graphene oxide nanosheets (GO): an electrochemical sensing platform for the sensitive and simultaneous determination of benzocaine in the presence of antipyrine
Analyst ( IF 3.6 ) Pub Date : 2017-08-10 00:00:00 , DOI: 10.1039/c7an01101f
Mona A. Mohamed 1, 2, 3, 4 , Shimaa A. Atty 1, 2, 3, 4 , Hanan A. Merey 4, 5, 6, 7, 8 , Taghreed A. Fattah 1, 2, 3, 4 , Christopher W. Foster 9, 10, 11, 12 , Craig E. Banks 9, 10, 11, 12
Affiliation  

An effective electrochemical sensing platform for the simultaneous determination of benzocaine (BEN) and antipyrine (ANT) based upon titanium dioxide nanoparticle (TiO2)/graphene oxide nanosheet (GO) bulk modified carbon paste electrodes (TiO2–GO/CPE) is reported. The TiO2–GO/CPE electrochemical sensing platform is found to exhibit linear ranges from 1.0 × 10−6 to 1.0 × 10−4 M and 1.2 × 10−8 to 8.0 × 10−5 M for BEN and ANT, respectively. The TiO2–GO/CPE sensor is explored towards the analysis of BEN and ANT in oral fluid (saliva) and pharmaceutical products. The synergy between the graphene oxide nanosheets and titanium dioxide nanoparticles results in a dramatic enhancement in the sensitivity of the sensor through a combination of increased surface area and improved electron transfer kinetics compared to other electrode alternatives. The fabricated TiO2–GO/CPE exhibits high sensitivity and good stability towards the sensing of BEN and ANT and has the potential to be utilised as a clinical assay and QA in pharmaceutical products.

中文翻译:

钛纳米颗粒(TiO 2)/氧化石墨烯纳米片(GO):在安替比林存在下灵敏同时测定苯甲卡因的电化学传感平台

报道了一种基于二氧化钛纳米颗粒(TiO 2)/氧化石墨烯纳米片(GO)块状修饰碳糊电极(TiO 2 –GO / CPE)的同时测定苯佐卡因(BEN)和安替比林(ANT)的有效电化学传感平台。发现TiO 2 –GO / CPE电化学传感平台的BEN和ANT线性范围分别为1.0×10 -6至1.0×10 -4 M和1.2×10 -8至8.0×10 -5M。TiO 2–GO / CPE传感器用于分析口腔液(唾液)和药品中的BEN和ANT。与其他电极替代品相比,通过增加表面积和改善电子转移动力学的组合,石墨烯氧化物纳米片和二氧化钛纳米粒子之间的协同作用显着提高了传感器的灵敏度。所制备的TiO 2 -GO / CPE对BEN和ANT的传感具有高灵敏度和良好的稳定性,并有可能被用作药物的临床分析和质量保证。
更新日期:2017-09-25
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