Total syntheses of schilancidilactones A and B, schilancitrilactone A, and 20-epi-schilancitrilactone A via late-stage nickel-catalyzed cross coupling,Chemical Science

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Total syntheses of schilancidilactones A and B, schilancitrilactone A, and 20-epi-schilancitrilactone A via late-stage nickel-catalyzed cross coupling
Chemical Science ( IF 7.6 ) Pub Date : 2017-08-30 00:00:00 , DOI: 10.1039/c7sc03293e
Hengtao Wang _{1,

2,

3,

4,

5} , Xiunan Zhang _{1,

2,

3,

4,

5} , Pingping Tang _{1,

2,

3,

4,

5}

Affiliation

The first total syntheses of schilancidilactones A and B, schilancitrilactone A, and 20-epi-schilancitrilactone A have been accomplished using a nickel-catalyzed cross coupling of alkyl bromide with vinyl stannane as the final step. The other key steps include late-stage C(sp³)–H bromination, the oxidative cleavage of a diol to provide the requisite ketone and ester for schilancidilactones A and B, and Dieckmann-type condensation to generate the A ring of schilancitrilactone A and 20-epi-schilancitrilactone A.

中文翻译：

schilancidilactones A和B，schilancitrilactone A的全合成，和20-外延-schilancitrilactone甲经由后期镍-催化的交叉偶联

使用镍催化的烷基溴化物与乙烯基锡烷的交叉偶联，完成了Schilancidilactones A和B，Schilancitrilaclactone A和20- epi- schilancitrilactonetone A的第一批总合成。其他关键步骤包括后期C（sp ³）–H溴化，二醇的氧化裂解以提供Schilancidilactones A和B所需的酮和酯，以及Dieckmann型缩合反应生成Schilancitrilaclactone A和A的A环。 20- Epi- schilancitrilactonetone A.

更新日期：2017-09-25

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