T-lymphocytes play a critical role in cancer immunity as evidenced by their presence in resected tumor samples derived from long-surviving patients, and impressive clinical responses to various immunotherapies that reinvigorate them. Indeed, tumors can upregulate a wide array of defense mechanisms, both direct and indirect, to suppress the ability of Tcells to reach the tumor bed and mount curative responses upon infiltration. In addition, patient and tumor genetics, previous antigenic experience, and the microbiome, are all important factors in shaping the T-cell repertoire and sensitivity to immunotherapy. Here, we review the mechanisms that regulate T-cell homing, infiltration, and activity within the solid tumor bed. Finally, we summarize different immunotherapies and combinatorial treatment strategies that enable the immune system to overcome barriers for enhanced tumor control and improved patient outcome.

中文翻译：

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实体肿瘤中调节T细胞浸润和活性的机制

T淋巴细胞在癌症免疫中起着至关重要的作用，这可以通过长期存活的患者所切除的肿瘤样本中的T淋巴细胞以及对各种免疫疗法的令人振奋的临床反应来证明。确实，肿瘤可以上调多种防御机制，包括直接和间接的防御机制，以抑制T细胞到达肿瘤床并在浸润后产生治愈反应的能力。此外，患者和肿瘤的遗传学，先前的抗原学经验以及微生物组，都是影响T细胞库和对免疫疗法敏感性的重要因素。在这里，我们审查了调节实体瘤床内T细胞归巢，浸润和活性的机制。最后，