The feasibility of utilizing high intensity focused ultrasound (HIFU) to induce thrombolysis has been demonstrated previously. However, clinical concerns still remain related to the clot debris produced via fragmentation of the original clot potentially being too large and hence occluding downstream vessels, causing hazardous emboli. This study investigates the use of standing wave fields formed via HIFU to disintegrate the thrombus while achieving a reduced clot debris size in vitro. The results showed that the average diameter of the clot debris calculated by volume percentage was smaller in the standing wave mode than in the travelling wave mode at identical ultrasound thrombolysis settings. Furthermore, the inertial cavitation dose was shown to be lower in the standing wave mode, while the estimated cavitation bubble size distribution was similar in both modes. These results show that a reduction of the clot debris size with standing waves may be attributed to the particle trapping of the acoustic pot...

中文翻译：

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使用通过高强度聚焦超声形成的驻波减少凝块碎片大小

先前已经证明了利用高强度聚焦超声 (HIFU) 诱导溶栓的可行性。然而，临床上的担忧仍然与通过原始凝块破碎产生的凝块碎片可能过大并因此阻塞下游血管，导致危险的栓塞有关。这项研究调查了使用通过 HIFU 形成的驻波场来分解血栓，同时在体外减少凝块碎片大小。结果表明，在相同的超声溶栓设置下，驻波模式中按体积百分比计算的凝块碎片的平均直径小于行波模式。此外，在驻波模式下惯性空化剂量显示较低，而估计的空化气泡尺寸分布在两种模式中相似。这些结果表明，随着驻波凝块碎片尺寸的减少可能归因于声波罐的粒子捕获......