Co‐Delivery of Drugs and Genes Using Polymeric Nanoparticles for Synergistic Cancer Therapeutic Effects,Advanced Healthcare Materials

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Co‐Delivery of Drugs and Genes Using Polymeric Nanoparticles for Synergistic Cancer Therapeutic Effects
Advanced Healthcare Materials ( IF 10.0 ) Pub Date : 2017-09-22 , DOI: 10.1002/adhm.201700886
Yi Li ₁ , Thavasyappan Thambi ₁ , Doo Sung Lee ₁

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Drug and gene delivery systems based on nanoparticles, microparticles and hydrogels have been widely studied for cancer treatment in the past decade. To achieve an efficient and safe delivery, selection of drug and gene delivery carrier is critical. Biocompatible polymeric nanoparticles are considerably promising carrier candidates in delivery of drugs and genes because of their unique chemical and physical properties. However, delivery of a drug or gene sometimes cannot achieve a satisfactory treatment effect. Therefore, co‐delivery of dual drugs or co‐delivery of a drug and a gene in a polymeric nanoparticle has attracted attention. Such co‐delivery systems can overcome multi‐drug resistance of chemical drugs and achieve a synergistic therapeutic effect. In this progress report, we summarize recent progress in the preparation and application of polymeric drug and gene co‐delivery nanosystems. The remaining challenges and future trends in this field are also included.

中文翻译：

使用高分子纳米颗粒共同递送药物和基因，以协同治疗癌症

在过去的十年中，已经广泛研究了基于纳米颗粒，微粒和水凝胶的药物和基因递送系统，用于癌症治疗。为了实现有效和安全的递送，选择药物和基因递送载体至关重要。生物相容性聚合物纳米粒子由于其独特的化学和物理特性，在药物和基因的传递中是非常有希望的载体候选者。但是，药物或基因的递送有时不能达到令人满意的治疗效果。因此，双重药物的共同递送或药物和基因在聚合纳米颗粒中的共同递送已引起关注。这种共同给药系统可以克服化学药物的多药耐药性，并达到协同治疗效果。在此进度报告中，我们总结了聚合物药物和基因共递送纳米系统的制备和应用方面的最新进展。还包括该领域中剩余的挑战和未来趋势。

更新日期：2017-09-22

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