Hydrogels self-assembled by biologically based building blocks including peptides and proteins can be used as an ideal drug delivery platform and present great promise for biomedical applications. Herein, photodynamic antitumor therapy based on injectable N-fluorenylmethoxycarbonyl diphenylalanine (Fmoc-FF)/poly-l-lysine (PLL) hydrogels was achieved by encapsulation of the photosensitive drug Chlorin e6 (Ce6), as the hydrogels exhibit multiple favorable therapeutic features, including shear-thinning and self-healing properties, good biocompatibility, and perfect biodegradability. Such injectable hydrogels are shown to be well-suited for local injection and sustained drug delivery at the tumor site, especially toward therapy of superficial tumors. In vivo therapeutic results show that the tumor growth can be efficiently inhibited, especially under the strategy “once injection, multiple-treatments”. During the whole treatment period, no detectable toxicity or damages to normal organs are observed. Therefore, the injectable hydrogels can be applied as a promising delivery platform for therapy of superficial tumors.

中文翻译：

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基于二肽纤维水凝胶结合光敏药物的抗肿瘤光动力疗法

由包括肽和蛋白质在内的生物基构件自组装的水凝胶可以用作理想的药物递送平台，并为生物医学应用提供了广阔的前景。本文中，基于可注射的N-芴基甲氧基羰基二苯丙氨酸（Fmoc-FF）/ poly- 1的光动力抗肿瘤治疗赖氨酸（PLL）水凝胶是通过封装光敏药物Chlorin e6（Ce6）制成的，因为水凝胶具有多种有利的治疗功能，包括剪切变稀和自我修复特性，良好的生物相容性以及完美的生物降解性。这种可注射的水凝胶被证明非常适合在肿瘤部位局部注射和持续给药，特别是对浅表肿瘤的治疗。体内治疗结果表明，可以有效地抑制肿瘤的生长，特别是在“一次注射，多次治疗”的策略下。在整个治疗期间，未观察到可检测到的毒性或对正常器官的损害。因此，可注射的水凝胶可以用作治疗浅表肿瘤的有希望的递送平台。