A novel, scalable strategy for the preparation of 2,3,4,6-tetrasubstituted pyridines is described. This protocol has two steps: an aminocatalyzed addition of ketones to alkylidene isoxazol-5-ones, followed by an iron-mediated decarboxylative cyclization event. Mechanistic insights for both steps are provided based on HRMS-ESI(+) studies.

中文翻译：

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氨基催化的迈克尔加成/铁介导的脱羧环化序列制备2,3,4,6-四取代的吡啶：范围和机制的见解。

描述了一种制备2,3,4,6-四取代吡啶的新颖，可扩展的策略。该方案有两个步骤：将氨基氨基催化的酮加成至亚烷基异恶唑-5-酮中，然后进行铁介导的脱羧环化反应。基于HRMS-ESI（+）研究，提供了这两个步骤的机械原理。