α-Helical peptide vesicles with chiral membranes as enantioselective nanoreactors,Chemical Communications

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α-Helical peptide vesicles with chiral membranes as enantioselective nanoreactors
Chemical Communications ( IF 4.3 ) Pub Date : 2017-09-13 00:00:00 , DOI: 10.1039/c7cc05869a
Xi Chen _{1,

2,

3,

4,

5} , Yanqiu Wang _{1,

2,

3,

4,

5} , Huaxin Wang _{1,

2,

3,

4,

5} , Yongju Kim _{1,

2,

3,

4,

5} , Myongsoo Lee _{1,

2,

3,

4,

5}

Affiliation

We report peptide vesicles with chiral membranes as enantioselective nanoreactors. The peptide vesicles are able to selectively encapsulate only a single enantiomer from a racemic mixture solution through preferential diffusion across the membranes. Notably, the confined space of the vesicle acts as an enantioselective nanoreactor for the encapsulated enantiomer which undergoes further chemical transformations to yield a highly enantiopure product.

中文翻译：

具有手性膜的α-螺旋肽囊泡作为对映选择性纳米反应器

我们报告与手性膜作为对映体选择性纳米反应器的肽囊泡。肽囊泡能够通过优先跨膜扩散而选择性地仅从外消旋混合物溶液中包封单个对映异构体。值得注意的是，囊泡的狭窄空间充当了被包封的对映异构体的对映选择性纳米反应器，该对映异构体经历了进一步的化学转化以产生高度对映纯的产物。

更新日期：2017-09-22

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