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Nickel-Catalyzed Reductive Transamidation of Secondary Amides with Nitroarenes
ACS Catalysis ( IF 11.3 ) Pub Date : 2017-09-22 00:00:00 , DOI: 10.1021/acscatal.7b02859 Chi Wai Cheung 1 , Marten Leendert Ploeger 1 , Xile Hu 1
ACS Catalysis ( IF 11.3 ) Pub Date : 2017-09-22 00:00:00 , DOI: 10.1021/acscatal.7b02859 Chi Wai Cheung 1 , Marten Leendert Ploeger 1 , Xile Hu 1
Affiliation
Transmidation is an attractive method for amide synthesis. However, transamidation of secondary amides is challenging. Here, we describe a reductive transamidation method that employs readily available nitro(hetero)arenes as the nitrogen sources, zinc or manganese as reductant, and simple nickel salt and ligand as a catalyst system. The scope of amides includes both alkyl and aryl secondary amides, with high functional group compatibility.
中文翻译:
硝基芳烃的镍催化仲酰胺还原转氨作用
氨基转移是酰胺合成的一种有吸引力的方法。然而,仲酰胺的转酰胺作用是具有挑战性的。在这里,我们描述了一种还原性转氨基方法,该方法采用容易获得的硝基(杂)芳烃作为氮源,锌或锰作为还原剂,简单的镍盐和配体作为催化剂体系。酰胺的范围包括具有高官能团相容性的烷基和芳基仲酰胺。
更新日期:2017-09-22
中文翻译:
硝基芳烃的镍催化仲酰胺还原转氨作用
氨基转移是酰胺合成的一种有吸引力的方法。然而,仲酰胺的转酰胺作用是具有挑战性的。在这里,我们描述了一种还原性转氨基方法,该方法采用容易获得的硝基(杂)芳烃作为氮源,锌或锰作为还原剂,简单的镍盐和配体作为催化剂体系。酰胺的范围包括具有高官能团相容性的烷基和芳基仲酰胺。