A novel strategy to control the generation of singlet oxygen by a photosensitizer using cucurbit[n]urils inclusion complexes is shown herein, and the strategy has great potential for therapeutic applications. We show the basic requirements of the photosensitizer complexes in order to develop an on–off switch for singlet oxygen that is reversible using competitive binding. The supramolecular strategy proposed in this paper avoids complex synthetic schemes in order to activate or deactivate the photosensitizer as previous work has shown and supports the use of biocompatible materials. Mechanistic insights into the control over the generation of singlet oxygen are provided, which strongly emphasize the key role of the cucurbit[n]uril macrocycles in the stabilization or deactivation of the triplet excited state.

中文翻译：

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使用葫芦[ n ] uril包合物配合物的单重态氧的超分子可逆通断开关

一种新的策略，通过使用葫芦[光敏剂来控制单线态氧的产生Ñ ]环联脲包合物在本文中被示出，并且该策略有用于治疗应用的巨大潜力。我们表现出为了发展光敏剂复合物的基本要求上-关闭开关的单线态氧是可逆的，通过竞争性结合。本文提出的超分子策略避免了复杂的合成方案，以激活或减活光敏剂，如先前的工作所示，并支持使用生物相容性材料。提供了有关控制单线态氧生成的机理的见解，这些见解强烈强调了葫芦科植物的关键作用[ n在三重态激发态的稳定或失活中存在] uril大环。