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Low antibody prevalence against Bacillus cereus biovar anthracis in Taï National Park, Côte d'Ivoire, indicates high rate of lethal infections in wildlife
PLOS Neglected Tropical Diseases ( IF 3.8 ) Pub Date : 2017-09-21 , DOI: 10.1371/journal.pntd.0005960
Fee Zimmermann , Susanne M. Köhler , Kathrin Nowak , Susann Dupke , Anne Barduhn , Ariane Düx , Alexander Lang , Hélène M. De Nys , Jan F. Gogarten , Roland Grunow , Emmanuel Couacy-Hymann , Roman M. Wittig , Silke R. Klee , Fabian H. Leendertz

Bacillus cereus biovar anthracis (Bcbva) is a member of the B. cereus group which carries both B. anthracis virulence plasmids, causes anthrax-like disease in various wildlife species and was described in several sub-Saharan African rainforests. Long-term monitoring of carcasses in Taï National Park, Côte d’Ivoire, revealed continuous wildlife mortality due to Bcbva in a broad range of mammalian species. While non-lethal anthrax infections in wildlife have been described for B. anthracis, nothing is known about the odds of survival following an anthrax infection caused by Bcbva. To address this gap, we present the results of a serological study of anthrax in five wildlife species known to succumb to Bcbva in this ecosystem. Specific antibodies were only detected in two out of 15 wild red colobus monkeys (Procolobus badius) and one out of 10 black-and-white colobus monkeys (Colobus polykomos), but in none of 16 sooty mangabeys (Cercocebus atys), 9 chimpanzees (Pan troglodytes verus) and 9 Maxwell’s duikers (Cephalophus maxwellii). The combination of high mortality and low antibody detection rates indicates high virulence of this disease across these different mammalian species.



中文翻译:

在科特迪瓦的塔伊国家公园,针对蜡状芽胞杆菌炭疽杆菌的抗体流行率低,这表明野生动植物的致死性感染率很高

蜡状芽胞杆菌炭疽杆菌(Bcbva)B的成员。同时携带B的蜡状菌群炭疽毒力质粒会在各种野生动植物物种中引起炭疽样疾病,并且在撒哈拉以南非洲的几种热带雨林中都有描述。对科特迪瓦的塔伊国家公园的cas体进行的长期监测显示,由于广泛的哺乳动物物种中的Bcbva造成的野生生物持续死亡。虽然B中描述了野生生物中非致命性炭疽的感染。炭疽病,由Bcbva引起的炭疽感染后的生存几率一无所知。为了解决这一差距,我们介绍了对五种已知在该生态系统中屈服于Bcbva的野生物种炭疽病的血清学研究结果。仅在15只野生红疣猴(Procolobus badius)和10只黑白疣猴(Colobus polykomos)中检出了特异性抗体,但在16个黑o(Cercocebus atys),9只黑猩猩(9只)中均未检测到特异性抗体。Pan troglodytes verus)和9个Maxwell's duikers(Cephalophus maxwellii )。高死亡率和低抗体检出率的组合表明,在这些不同的哺乳动物物种中,该病具有高毒力。

更新日期:2017-09-21
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