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Universal Equations for the Coalescence Probability and Long-Term Size Stability of Phospholipid-Coated Monodisperse Microbubbles Formed by Flow Focusing
Langmuir ( IF 3.7 ) Pub Date : 2017-09-21 00:00:00 , DOI: 10.1021/acs.langmuir.7b02547
Tim Segers 1 , Detlef Lohse 2 , Michel Versluis 2 , Peter Frinking 1
Affiliation  

Resonantly driven monodisperse phospholipid-coated microbubbles are expected to substantially increase the sensitivity and efficiency in contrast-enhanced ultrasound imaging and therapy. They can be produced in a microfluidic flow-focusing device, but questions remain as to the role of the device geometry, the liquid and gas flow, and the phospholipid formulation on bubble stability. Here, we develop a model based on simple continuum mechanics equations that reveals the scaling of the coalescence probability with the key physical parameters. It is used to characterize short-term coalescence behavior and long-term size stability as a function of flow-focusing geometry, bulk viscosity, lipid cosolvent mass fraction, lipid concentration, lipopolymer molecular weight, and lipopolymer molar fraction. All collected data collapse on two master curves given by universal equations for the coalescence probability and the long-term size stability. This work is therefore a route to a more fundamental understanding of the physicochemical monolayer properties of microfluidically formed bubbles and their coalescence behavior in a flow-focusing device.

中文翻译:

流动聚焦形成的磷脂包覆的单分散微泡的聚结概率和长期尺寸稳定性的通用方程

共振驱动的单分散磷脂包被的微泡有望大大提高造影剂增强型超声成像和治疗的灵敏度和效率。它们可以在微流聚焦装置中生产,但是仍然存在关于装置几何形状,液体和气体流动以及磷脂制剂对气泡稳定性的作用的问题。在这里,我们基于简单的连续力学方程式开发了一个模型,该模型揭示了关键物理参数对合并概率的缩放。它用于表征短期聚结行为和长期尺寸稳定性,这些特性是流动聚焦几何形状,体积粘度,脂质助溶剂质量分数,脂质浓度,脂聚合物分子量和脂聚合物摩尔分数的函数。所有收集到的数据折叠在由通用方程式给出的两条主曲线上,以体现合并概率和长期尺寸稳定性。因此,这项工作是对流体形成装置中微流体形成的气泡的物理化学单层性质及其聚结行为有更基本认识的途径。
更新日期:2017-09-21
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