Our official English website, www.x-mol.net, welcomes your
feedback! (Note: you will need to create a separate account there.)
Scarless Wound Closure by a Mussel-Inspired Poly(amidoamine) Tissue Adhesive with Tunable Degradability
ACS Omega ( IF 3.7 ) Pub Date : 2017-09-21 00:00:00 , DOI: 10.1021/acsomega.7b01221 Bo Peng 1, 1, 2 , Xinyi Lai 1, 1 , Lei Chen 3 , Xuemei Lin 1, 1 , Chengxin Sun 1, 1 , Lixin Liu 1, 1 , Shaohai Qi 3 , Yongming Chen 1, 1 , Kam W Leong 2
ACS Omega ( IF 3.7 ) Pub Date : 2017-09-21 00:00:00 , DOI: 10.1021/acsomega.7b01221 Bo Peng 1, 1, 2 , Xinyi Lai 1, 1 , Lei Chen 3 , Xuemei Lin 1, 1 , Chengxin Sun 1, 1 , Lixin Liu 1, 1 , Shaohai Qi 3 , Yongming Chen 1, 1 , Kam W Leong 2
Affiliation
|
Burn, trauma, and various medical conditions including bacterial infection, diabetes complication, and surgery could lead to an acute cutaneous wound and scar formation. Application of tissue glues instead of sutures could minimize the additional trauma and scar formation. Despite the countless efforts devoted to the development of high-strength tissue glues, little attention has been paid to their influence on the scar formation. Here, we report the development of a new tissue glue with excellent biocompatibility and tunable degradability for scarless wound closure. A series of catechol-containing poly(amidoamine) (CPAA) polymers were synthesized via the one-step Michael addition of dopamine and bisacrylamide. The tertiary amino group in the polymer backbone was used to introduce a zwitterionic sulfobetaine group by one-step ring-opening polymerization. The introduction of the zwitterionic sulfobetaine group could easily tune the hydrophilicity and the degradability of CPAA without influencing the density of the catechol group in the polymer. Lap-shear tests on the porcine skin demonstrated a high adhesion strength of 7 kPa at 1 h, rising to 24 kPa by 12 h. Addition of silica nanoparticles could further enhance the adhesion strength by 50%. In vivo studies further confirmed that the CPAA tissue glue could effectively accelerate the healing process of incisional wounds on the back of Sprague Dawley rats compared with suture and reduce the scar formation.
中文翻译：
采用具有可调节降解性的受贻贝启发的聚（酰胺基胺）组织粘合剂实现无疤痕伤口闭合
烧伤、创伤和各种医疗状况，包括细菌感染、糖尿病并发症和手术，都可能导致急性皮肤伤口和疤痕形成。使用组织胶代替缝合线可以最大限度地减少额外的创伤和疤痕形成。尽管为开发高强度组织胶付出了无数的努力，但很少有人关注它们对疤痕形成的影响。在这里，我们报告了一种新型组织胶的开发，该胶具有优异的生物相容性和可调节的降解性，可实现无疤痕伤口闭合。通过多巴胺和双丙烯酰胺的一步迈克尔加成反应合成了一系列含儿茶酚的聚酰胺胺（CPAA）聚合物。利用聚合物主链中的叔氨基通过一步开环聚合引入两性离子磺基甜菜碱基团。两性离子磺基甜菜碱基团的引入可以轻松调节CPAA的亲水性和降解性，而不影响聚合物中儿茶酚基团的密度。对猪皮的搭接剪切测试表明，1 小时时粘合强度高达 7 kPa，12 小时时升至 24 kPa。添加二氧化硅纳米颗粒可以进一步提高粘合强度50%。体内研究进一步证实，与缝线相比，CPAA组织胶能有效加速Sprague Dawley大鼠背部切口伤口的愈合过程，减少疤痕形成。
更新日期：2017-09-21
中文翻译：
采用具有可调节降解性的受贻贝启发的聚（酰胺基胺）组织粘合剂实现无疤痕伤口闭合
烧伤、创伤和各种医疗状况，包括细菌感染、糖尿病并发症和手术，都可能导致急性皮肤伤口和疤痕形成。使用组织胶代替缝合线可以最大限度地减少额外的创伤和疤痕形成。尽管为开发高强度组织胶付出了无数的努力，但很少有人关注它们对疤痕形成的影响。在这里，我们报告了一种新型组织胶的开发，该胶具有优异的生物相容性和可调节的降解性，可实现无疤痕伤口闭合。通过多巴胺和双丙烯酰胺的一步迈克尔加成反应合成了一系列含儿茶酚的聚酰胺胺（CPAA）聚合物。利用聚合物主链中的叔氨基通过一步开环聚合引入两性离子磺基甜菜碱基团。两性离子磺基甜菜碱基团的引入可以轻松调节CPAA的亲水性和降解性，而不影响聚合物中儿茶酚基团的密度。对猪皮的搭接剪切测试表明，1 小时时粘合强度高达 7 kPa，12 小时时升至 24 kPa。添加二氧化硅纳米颗粒可以进一步提高粘合强度50%。体内研究进一步证实，与缝线相比，CPAA组织胶能有效加速Sprague Dawley大鼠背部切口伤口的愈合过程，减少疤痕形成。
京公网安备 11010802027423号