Regio- and Stereoselective Chlorocyanation of Alkynes,Angewandte Chemie International Edition

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Regio- and Stereoselective Chlorocyanation of Alkynes
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2017-09-21 08:45:48 , DOI: 10.1002/anie.201705851
Alejandro G. Barrado ₁ , Adam Zieliński ₁ , Richard Goddard ₂ , Manuel Alcarazo ₁

Affiliation

Ready, willing, able: Alkynes were converted into (Z)-3-chloroacrylonitriles by the use of imidazolium thiocyanates as electrophilic cyanating reagents in a transformation found to be efficient (fast at room temperature), versatile (24 examples, internal and terminal alkynes), and selective (excellent regio- and stereoselectivity; see scheme). The products could be readily functionalized to provide useful building blocks.

中文翻译：

炔烃的区域和立体选择性氯氰化

准备，愿意，能够：通过使用硫氰酸咪唑鎓盐作为亲电子氰化试剂，将炔烃转化为（Z）-3-氯丙烯腈，发现该转化有效（在室温下快速），通用（24例，内部和末端炔烃））和选择性（出色的区域选择性和立体选择性；请参阅方案）。产品可以很容易地功能化以提供有用的构建基块。

更新日期：2017-09-21

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