Biosensing methods for the detection of highly pathogenic avian influenza H5N1 and H7N9 viruses,Analytical Methods

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Biosensing methods for the detection of highly pathogenic avian influenza H5N1 and H7N9 viruses
Analytical Methods ( IF 2.7 ) Pub Date : 2017-08-31 00:00:00 , DOI: 10.1039/c7ay01585b
Zhanming Li _{1,

2,

3,

4,

5} , Yingchun Fu _{1,

2,

3,

4} , Ming Liao _{4,

6,

7,

8} , Yanbin Li _{1,

2,

3,

4,

9}

Affiliation

The highly pathogenic avian influenza (HPAI) H5N1 and H7N9 viruses may lead to the next pandemic if human-to-human transmissibility is established because the host range restriction can be changed via virus mutations or reassortments. Therefore, effective and efficient detection methods are crucial for the early stage identification and surveillance of an outbreak of HPAI viruses. In this review, viral mutation and pathogenicity are briefly introduced first. Then, traditional detection methods, including virus isolation, immunoassays, and molecular biology methods, for H5N1 and H7N9 viruses are presented in detail. Finally, the state of the art in biosensing methods for the detection of H5N1 and H7N9 viruses is presented and discussed with an emphasis on advances made in biosensors. Future developments may make biosensing methods more accessible for low-cost and point-of-care application.

中文翻译：

用于检测高致病性禽流感H5N1和H7N9病毒的生物传感方法

高致病性禽流感，如果人对人的传播能力是建立，因为宿主范围限制是可以改变的（HPAI）H5N1和H7N9病毒可能会导致下一次大流行通过病毒突变或重组。因此，有效和有效的检测方法对于HPAI病毒爆发的早期识别和监视至关重要。在这篇综述中，首先简要介绍了病毒突变和致病性。然后，详细介绍了H5N1和H7N9病毒的传统检测方法，包括病毒分离，免疫测定和分子生物学方法。最后，介绍并讨论了用于检测H5N1和H7N9病毒的生物传感方法的最新技术，重点是在生物传感器方面取得的进展。未来的发展可能会为低成本和即时医疗应用提供更多的生物传感方法。

更新日期：2017-09-21

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