A ruthenium-nitrosyl-functionalized nanoplatform for the targeting of liver cancer cells and NIR-light-controlled delivery of nitric oxide combined with photothermal therapy,Journal of Materials Chemistry B

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A ruthenium-nitrosyl-functionalized nanoplatform for the targeting of liver cancer cells and NIR-light-controlled delivery of nitric oxide combined with photothermal therapy
Journal of Materials Chemistry B ( IF 6.1 ) Pub Date : 2017-09-12 00:00:00 , DOI: 10.1039/c7tb02059g
Yan-Hui Li _{1,

2,

3,

4,

5} , Min Guo _{1,

2,

3,

4,

5} , Shu-Wen Shi _{1,

2,

3,

4,

5} , Qian-Ling Zhang _{5,

6,

7,

8,

9} , Shi-Ping Yang _{4,

5,

10,

11} , Jin-Gang Liu _{1,

2,

3,

4,

5}

Affiliation

The development of light-controlled nitric oxide (NO)-releasing nanoplatforms that are capable of specifically targeting liver cancer cell lines and delivering an optimal amount of NO can significantly affect liver cancer therapy. In this study, a multifunctional nanoplatform {N-GQDs@Ru-NO@Gal} (1) for the near-infrared (NIR) light-responsive release of NO, consisting of a NO donor (Ru-NO) and a liver-targeting galactose derivative (Gal) covalently attached to N-doped graphene quantum dots (N-GQDs), was reported. Nanoplatform 1 preferentially targeted liver cancer cells over normal cells and instantly released NO as well as exhibited a prominent photothermal effect upon NIR irradiation at 808 nm, thereby leading to efficient anti-tumor efficacy. {N-GQDs@Ru-NO@Gal} with a small size (<10 nm), good biocompatibility, and fluorescent-tracing properties represents a unique example of a multifunctional NO-releasing nanoplatform that combines photodynamic and photothermal therapies for the targeted treatment of liver cancer. Hence, the developed nanoplatform demonstrates potential for applications in NO-mediated multimodal phototherapy in the near future.

中文翻译：

钌-亚硝酰基官能化的纳米平台，用于靶向肝癌细胞和一氧化氮的近红外光控制递送，结合光热疗法

能够特异性靶向肝癌细胞系并递送最佳NO的光控释放一氧化氮（NO）的纳米平台的开发，可以显着影响肝癌的治疗。在这项研究中，一种多功能纳米平台{N-GQDs @ Ru-NO @ Gal}（1）用于NO的近红外（NIR）光响应性释放，由NO供体（Ru-NO）和肝脏报道了靶向共价连接到N掺杂石墨烯量子点（N-GQDs）的半乳糖衍生物（Gal）。纳米平台1优先靶向肝癌细胞而不是正常细胞，并立即释放NO，并且在808 nm的NIR照射下表现出突出的光热效应，从而导致有效的抗肿瘤功效。具有较小尺寸（<10 nm），良好的生物相容性和荧光示踪特性的{N-GQDs @ Ru-NO @ Gal}代表了多功能NO释放纳米平台的独特示例，该平台结合了光动力疗法和光热疗法进行靶向治疗肝癌。因此，开发的纳米平台在不久的将来证明了其在NO介导的多模式光疗中的应用潜力。

更新日期：2017-09-21

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