Iridium-catalyzed direct C–H amidation of anilines with sulfonyl azides: easy access to 1,2-diaminobenzenes,Organic & Biomolecular Chemistry

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Iridium-catalyzed direct C–H amidation of anilines with sulfonyl azides: easy access to 1,2-diaminobenzenes
Organic & Biomolecular Chemistry ( IF 2.9 ) Pub Date : 2017-09-13 00:00:00 , DOI: 10.1039/c7ob01899a
Lianhui Wang _{1,

2,

3,

4,

5} , Zi Yang _{1,

2,

3,

4,

5} , Mengqi Yang _{1,

2,

3,

4,

5} , Rongyi Zhang _{1,

2,

3,

4,

5} , Changsheng Kuai _{1,

2,

3,

4,

5} , Xiuling Cui _{1,

2,

3,

4,

5}

Affiliation

An Ir(III)-catalyzed regioselective C–H amidation of anilines with sulfonyl azides is described. The developed protocol has good compatibility with diverse functional groups, efficiently providing the monoamidated products with good to excellent yields under mild reaction conditions. Furthermore, the 2-pyrimidyl and sulfonyl moieties in the amidated products can readily be removed, offering the synthetically useful 1,2-diaminobenzene scaffold.

中文翻译：

铱与磺酰叠氮化物的铱催化苯胺直接CH-H酰胺化反应：容易获得1,2-二氨基苯

描述了一种Ir（III）催化的苯胺与磺酰叠氮化物的区域选择性CH酰胺化反应。所开发的方案与各种官能团具有良好的相容性，可在温和的反应条件下有效地为单酰胺化产物提供良好或优异的收率。此外，可以容易地除去酰胺化产物中的2-嘧啶基和磺酰基部分，从而提供了合成上有用的1，2-二氨基苯支架。

更新日期：2017-09-21

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