TPZ, a bright centrosymmetric two-photon scaffold for bioimaging,Chemical Communications

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TPZ, a bright centrosymmetric two-photon scaffold for bioimaging
Chemical Communications ( IF 4.3 ) Pub Date : 2017-09-13 00:00:00 , DOI: 10.1039/c7cc06031a
Zuhai Lei _{1,

2,

3,

4,

5} , Ping Yue _{5,

6,

7,

8} , Xueli Wang _{5,

9,

10,

11} , Xinran Li _{1,

2,

3,

4,

5} , Yi Li _{1,

2,

3,

4,

5} , Haihong He _{1,

2,

3,

4,

5} , Xiao Luo _{1,

2,

3,

4,

5} , Xiangming Meng _{5,

6,

7,

8} , Jinquan Chen _{5,

9,

10,

11} , Xuhong Qian _{1,

2,

3,

4,

5} , Youjun Yang _{1,

2,

3,

4,

5}

Affiliation

The development of biocompatible two-photon fluorophores with a large absorption cross-section is challenging, despite the presence of theoretical guidelines. By rendering asymmetric PRODAN dye centrosymmetric, we designed and synthesized a novel class of two-photon fluorophores (TPZ). Their photophysical properties were investigated and their imaging potentials in cells, tissues and zebrafish were showcased.

中文翻译：

TPZ，一种用于生物成像的明亮的中心对称双光子支架

尽管存在理论指导，但具有大吸收截面的生物相容性双光子荧光团的开发仍具有挑战性。通过使不对称PRODAN染料呈中心对称，我们设计并合成了一类新型的双光子荧光团（TPZ）。研究了它们的光物理性质，并展示了它们在细胞，组织和斑马鱼中的成像潜力。

更新日期：2017-09-21

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