The selective hydrolysis of the glycosidic bond between the terminal sialic acid and the penultimate sugar has been achieved in the alpha-2-HS-glycoprotein (Fetuin-A) in the presence of H₃PW₁₂O₄₀, a Keggin type polyoxometalate. A controlled liberation of sialic acid from the glycoprotein could be achieved at pH 3.0 and 37 °C without the destruction of the protein backbone.

中文翻译：

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多金属氧酸盐模拟唾液酸酶：从磷钨酸促进的糖蛋白中选择性无损地去除唾液酸

在存在H ₃ PW ₁₂ O ₄₀（Keggin型多金属氧酸盐）的情况下，在alpha-2-HS-糖蛋白（Fetuin-A）中实现了末端唾液酸和倒数第二个糖之间糖苷键的选择性水解。在pH 3.0和37°C的条件下，可以实现唾液酸从糖蛋白的受控释放，而不会破坏蛋白骨架。