Clustering of PK-trisaccharides on amphiphilic cyclodextrin reveals unprecedented affinity for the Shiga-like toxin Stx2,Chemical Communications

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Clustering of PK-trisaccharides on amphiphilic cyclodextrin reveals unprecedented affinity for the Shiga-like toxin Stx2
Chemical Communications ( IF 4.3 ) Pub Date : 2017-08-31 00:00:00 , DOI: 10.1039/c7cc06299k
Ping Zhang _{1,

2,

3,

4,

5} , Eugenia Paszkiewicz _{1,

2,

6,

7,

8} , Qifang Wang _{1,

2,

3,

4,

5} , Joanna M. Sadowska _{1,

2,

6,

7,

8} , Pavel I. Kitov _{1,

2,

6,

7,

8} , David R. Bundle _{1,

2,

6,

7,

8} , Chang-Chun Ling _{1,

2,

3,

4,

5}

Affiliation

Using amphiphilic cyclodextrin as a scaffold, the first class of P^K-glycoconjugates capable of high avidity binding to both Stx1 and Stx2 toxins in solid-phase assay formats is reported. The generated glycomicroarray effectively mimics the plasma membrane surface while discriminating binding of the two Stx toxins, with unprecedented affinity to Stx2.

中文翻译：

P的聚类^ķ两亲环糊精-trisaccharides揭示为志贺样毒素的Stx2前所未有亲和力

使用两亲性环糊精作为支架，第一类P的^ķ -glycoconjugates能够高亲合力结合于固相分析形式都STX1和Stx2的毒素被报告。产生的糖微阵列可有效模拟质膜表面，同时区分两种Stx毒素的结合，并且对Stx2具有空前的亲和力。

更新日期：2017-09-21

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