Prion-like domains have emerged as important drivers of neurodegenerative disease. Now, Boulay et al. establish that the translocated prion-like domain of the oncogenic EWS-FLI1 fusion protein enables phase-separation events, which inappropriately recruit chromatin-remodeling factors to elicit the aberrant transcriptional programs underlying Ewing's sarcoma.

中文翻译：

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类病毒的领域计划尤因氏肉瘤。

on病毒样结构域已成为神经退行性疾病的重要驱动因素。现在，Boulay等人。证实了致癌的EWS-FLI1融合蛋白的易位病毒样结构域能够实现相分离事件，该相分离事件不适当地募集了染色质重塑因子来引发尤文氏肉瘤的异常转录程序。