A concise synthesis of the AE bicyclic system of Daphniphyllum alkaloid yuzurine is described. The synthetic sequence features a Dieckmann condensation to construct ring A, reduction of α, β-unsaturated double bond and propargylation of α-position of lactone to diastereoselectively generate relative stereocenter C-3, C-4 and C-5, and an acid-catalyzed cyclization to assemble ring E.

中文翻译：

---

的AE双环的合成虎皮楠生物碱yuzurine

的AE双环系统的简明合成虎皮生物碱yuzurine进行说明。合成序列的特征是通过Dieckmann缩合反应来构建环A，还原α，β-不饱和双键和内酯的α-位炔丙基化以非对映选择性地产生相对的立体中心C-3，C-4和C-5，以及酸-催化环化以组装环E。