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[bmIm]OH catalyzed coupling: Green and efficient synthesis of 2,8 dioxacyclopenta [a] inden-3-one derivatives in an aqua media
Tetrahedron Letters ( IF 1.5 ) Pub Date : 2017-09-21 , DOI: 10.1016/j.tetlet.2017.09.039
Malik A Waseem , Shireen , Khursheed Ansari , Farah Ibad , Afshan Ibad , Jagdamba Singh , I.R. Siddiqui

An efficient recyclable [bmIm]OH catalyzed and aqua mediated eco-compatible synthesis of biologically versatile 2,8 dioxacyclopenta [a] inden-3-one derivatives. Combination of ionic liquid and water has emerged out as a powerful synthetic tool for constructing C–C, C–S and C–O bonds. Disclosed methodology for introducing broad range of 2-iodophenols, 2-iodothiophenols and tetronic acid in basic ionic liquid with predictable high yield will catch the attention of synthetic chemists. This protocol has documented the notable advances and the applications of ionic liquid in heterocyclic synthesis. The chosen strategy illustrates important issues regarding scope, reactivity, product yield, reaction time, reuse and recyclability that will help in designing new synthetic routes for other heterocyclic synthesis.



中文翻译:

[bmIm] OH催化偶联:在水介质中绿色高效合成2,8 dioxacyclopenta [ a ] inden-3-one衍生物

一种有效的可循环利用的[bmIm] OH催化和水介导的生物通用2,8二氧杂环戊环[ a ] inden-3-one衍生物的水相容性生态相容性合成。离子液体和水的结合已成为构建C–C,C–S和C–O键的强大合成工具。在碱性离子液体中以可预见的高产率引入广泛的2-碘苯酚,2-碘硫代苯酚和tetronic酸的公开方法将引起合成化学家的关注。该方案记录了离子液体在杂环合成中的显着进展和应用。选择的策略说明了有关范围,反应性,产物收率,反应时间,再利用和可回收性的重要问题,这将有助于设计用于其他杂环合成的新合成路线。

更新日期:2017-09-21
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