The Human Proteome is nearly fully mapped and will provide a knowledge base to accelerate our understanding of how proteins and protein networks can affect human health and disease. However, providing solutions to human health challenges will likely fail if insights are exclusively based on studies of human samples and human proteomes. In recent years, it has become evident that human health depends on an integrated understanding of the many species that make human life possible. These include the commensal microorganisms which are essential to human life, pathogens and food species as well as the classic model organisms that enable studies of biological mechanisms. The Human Proteome Organization (HUPO) initiative on multi-organism proteomes (iMOP) works to support proteome research undertaken on non-human species which remain widely under-studied compared to the progress in human proteome research. This perspective argues the need for further research on multiple species that impact human life. We also present an update on recent progress in model organisms, microbiota, and food species, address the emerging problem of antibiotics resistance, and outline how iMOP activities could lead to a more inclusive approach for the human proteome project (HPP) to better support proteome research aimed at improving human health and furthering knowledge on human biology.

中文翻译：

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我们并不孤单：iMOP计划及其在生物学和疾病驱动的人类蛋白质组计划中的作用。

人类蛋白质组图谱几乎完整，将提供一个知识库，以加快我们对蛋白质和蛋白质网络如何影响人类健康和疾病的理解。但是，如果仅基于对人类样本和人类蛋白质组的研究得出的见解，则无法提供应对人类健康挑战的解决方案。近年来，显而易见的是，人类健康取决于对使人类生活成为可能的许多物种的综合理解。这些包括对人类生命，病原体和食物物种必不可少的共生微生物，以及能够进行生物学机制研究的经典模式生物。人类蛋白质组学组织（HUPO）关于多生物蛋白质组学（iMOP）的倡议旨在支持针对非人类物种进行的蛋白质组学研究，与人类蛋白质组学研究的进展相比，该研究仍被广泛研究。这种观点认为有必要对影响人类生活的多种物种进行进一步研究。我们还提供了有关模型生物，微生物群和食物种类的最新进展的最新信息，解决了新出现的抗生素耐药性问题，并概述了iMOP的活动如何为人类蛋白质组计划（HPP）带来更具包容性的方法，以更好地支持蛋白质组学旨在改善人类健康和增进人类生物学知识的研究。