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New Insights into Genome Structure: Genes of a Feather Stick Together
Molecular Cell ( IF 14.5 ) Pub Date : 2017-09-19 , DOI: 10.1016/j.molcel.2017.08.023 Denes Hnisz , Richard A. Young
中文翻译:
基因组结构的新见解:羽毛粘在一起的基因
更新日期:2017-09-19
Molecular Cell ( IF 14.5 ) Pub Date : 2017-09-19 , DOI: 10.1016/j.molcel.2017.08.023 Denes Hnisz , Richard A. Young
DNA structuring proteins such as CTCF facilitate DNA loop formation and are presumed to be among the major determinants of eukaryotic genome structure. Recent studies, including Rowley et al. (2017), suggest that gene activation and repression play fundamentally important roles in structuring the genome independently of CTCF.
中文翻译:
基因组结构的新见解:羽毛粘在一起的基因
DNA结构蛋白(例如CTCF)促进DNA环的形成,并被认为是真核基因组结构的主要决定因素之一。最近的研究,包括Rowley等。(2017),表明基因激活和抑制在独立于CTCF构建基因组方面起着根本性的重要作用。