Remote Migratory Cross-Electrophile Coupling and Olefin Hydroarylation Reactions Enabled by in Situ Generation of NiH,Journal of the American Chemical Society

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Remote Migratory Cross-Electrophile Coupling and Olefin Hydroarylation Reactions Enabled by in Situ Generation of NiH
Journal of the American Chemical Society ( IF 14.4 ) Pub Date : 2017-09-20 00:00:00 , DOI: 10.1021/jacs.7b08064
Fenglin Chen ₁ , Ke Chen ₁ , Yao Zhang ₁ , Yuli He ₁ , Yi-Ming Wang ₂ , Shaolin Zhu ₁

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A highly efficient strategy for remote reductive cross-electrophile coupling has been developed through the ligand-controlled nickel migration/arylation. This general protocol allows the use of abundant and bench-stable alkyl bromides and aryl bromides for the synthesis of a wide range of structurally diverse 1,1-diarylalkanes in excellent yields and high regioselectivities under mild conditions. We also demonstrated that alkyl bromide could be replaced by the proposed olefin intermediate while using n-propyl bromide/Mn⁰ as a potential hydride source.

中文翻译：

NiH的原位产生远程迁移性亲电子偶联和烯烃氢化反应

通过配体控制的镍迁移/芳构化，已经开发出一种用于远程还原性交亲电试剂偶联的高效策略。该通用方案允许使用大量稳定的烷基溴化物和芳基溴化物，在温和条件下以优异的收率和高区域选择性合成各种结构多样的1,1-二芳基烷烃。我们还证明，在使用正丙基溴/ Mn ⁰作为潜在的氢化物源的同时，烷基溴可以被提议的烯烃中间体替代。

更新日期：2017-09-20

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