Metformin, an Anthropogenic Contaminant of Seidlitzia rosmarinus Collected in a Desert Region near the Gulf of Aqaba, Sinai Peninsula,Journal of Natural Products

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Metformin, an Anthropogenic Contaminant of Seidlitzia rosmarinus Collected in a Desert Region near the Gulf of Aqaba, Sinai Peninsula
Journal of Natural Products ( IF 3.3 ) Pub Date : 2017-09-20 00:00:00 , DOI: 10.1021/acs.jnatprod.7b00106
Ahmed R. Hassan _{1,

2} , Salah M. El-Kousy ₃ , Sayed A. El-Toumy ₄ , Karla Frydenvang ₁ , Truong Thanh Tung ₁ , Jesper Olsen ₅ , John Nielsen ₁ , Søren Brøgger Christensen ₁

Affiliation

A phytochemical investigation of Seidlitzia rosmarinus collected along the shoreline of the Gulf of Aqaba in the remote southern desert region of the Sinai peninsula has revealed the presence of the registered drug metformin (4). However, analysis of the ¹⁴C content revealed the drug to be an anthropogenic contaminant. Consequently, natural product researchers should be aware that compounds isolated from plants might originate from environmental contamination rather than biosynthesis. The new natural product N-(4-hydroxyphenylethyl)-α-chloroferuloylamide was isolated as a mixture of the E and Z isomers along with a number of other well-established secondary metabolites.

中文翻译：

二甲双胍，迷迭香中的一种人为污染菌，收集在西奈半岛亚喀巴湾附近的一个沙漠地区

在西奈半岛偏远南部沙漠地区沿亚喀巴湾海岸线收集的玫瑰色罗汉果（Seidlitzia rosmarinus）的植物化学调查显示，已存在注册的二甲双胍药物（4）。但是，对¹⁴ C含量的分析表明该药物是人为污染物。因此，天然产物的研究人员应意识到，从植物中分离出的化合物可能源自环境污染而不是生物合成。新的天然产物ñ - （4-羟基苯基乙基）- α - chloroferuloylamide分离为的混合物ë和ž 异构体以及许多其他公认的次生代谢产物。

更新日期：2017-09-20

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