Validation of a 52-gene risk profile for outcome prediction in patients with idiopathic pulmonary fibrosis: an international, multicentre, cohort study.,The Lancet

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Validation of a 52-gene risk profile for outcome prediction in patients with idiopathic pulmonary fibrosis: an international, multicentre, cohort study.
The Lancet ( IF 98.4 ) Pub Date : 2017-11-01 , DOI: 10.1016/s2213-2600(17)30349-1
Jose D Herazo-Maya ₁ , Jiehuan Sun ₂ , Philip L Molyneaux ₃ , Qin Li ₄ , Julian A Villalba ₅ , Argyrios Tzouvelekis ₄ , Heather Lynn ₄ , Brenda M Juan-Guardela ₁ , Cristobal Risquez ₃ , Juan C Osorio ₃ , Xiting Yan ₄ , George Michel ₄ , Nachelle Aurelien ₁ , Kathleen O Lindell ₆ , Melinda J Klesen ₆ , Miriam F Moffatt ₃ , William O Cookson ₃ , Yingze Zhang ₆ , Joe G N Garcia ₇ , Imre Noth ₈ , Antje Prasse ₉ , Ziv Bar-Joseph ₁₀ , Kevin F Gibson ₆ , Hongyu Zhao ₂ , Erica L Herzog ₄ , Ivan O Rosas ₅ , Toby M Maher ₁₁ , Naftali Kaminski ₄

Affiliation

Section of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, Yale School of Medicine, Yale University, New Haven, CT, USA; Section of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, NCH Healthcare System and Mayo Clinic School of Medicine, Naples, FL, USA.
Department of Biostatistics, Yale School of Public Health, Yale University, New Haven, CT, USA.
National Heart and Lung Institute, Imperial College London, London, UK.
Section of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, Yale School of Medicine, Yale University, New Haven, CT, USA.
Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Department of Medicine and University of Arizona Respiratory Center, University of Arizona, Tucson, AZ, USA.
Section of Pulmonary and Critical Care Medicine, Department of Medicine, University of Chicago, Chicago, IL, USA.
Department of Pneumology, Hannover Medical School, Hannover, Germany; University Clinical Center Freiburg, Department of Pneumology, Freiburg, Germany.
Computational Biology Department, School of Computer Science, Carnegie Mellon University, Pittsburgh, PA, USA.
National Heart and Lung Institute, Imperial College London, London, UK; National Institute for Health Research, Respiratory Biomedical Research Unit, Royal Brompton Hospital, London, UK.

The clinical course of idiopathic pulmonary fibrosis (IPF) is unpredictable. Clinical prediction tools are not accurate enough to predict disease outcomes.

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