Matthias Maiwald and Andreas Widmer express concern with the WHO recommendation on surgical site preparation.^1,2 WHO guidelines are developed using processes and methods to ensure robust recommendations.³ Specifically, this recommendation was informed by a systematic review and several meta-analyses, including one of six randomised controlled trials comparing alcohol-based chlorhexidine with povidone-iodine-alcohol (PVP-I) preparations that showed a greater reduction in surgical site infections (SSIs) with chlorhexidine (odds ratio [OR] 0·58, 95% CI 0·42–0·80).

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世卫组织关于外科手术皮肤消毒的建议为时过早–作者的回复

Matthias Maiwald和Andreas Widmer对WHO关于手术部位准备的建议表示关注。^1,2 WHO指南是使用流程和方法制定的，以确保提出有力的建议。³具体来说，该建议是通过系统综述和多项荟萃分析得出的，其中包括比较以酒精为基础的洗必泰和聚维酮碘酒（PVP-1）制剂进行比较的六项随机对照试验中的一项，该试验显示，手术部位感染的减少幅度更大（SSI）与洗必泰（赔率[OR] 0·58，95％CI 0·42-0·80）。