Organocatalytic Asymmetric Synthesis of 3,3-Disubstituted 3,4-Dihydro-2-quinolones,Advanced Synthesis & Catalysis

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Organocatalytic Asymmetric Synthesis of 3,3-Disubstituted 3,4-Dihydro-2-quinolones
Advanced Synthesis & Catalysis ( IF 4.4 ) Pub Date : 2017-09-20 06:06:24 , DOI: 10.1002/adsc.201700655
Soumendranath Mukhopadhyay ₁ , Utpal Nath ₁ , Subhas Chandra Pan ₁

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The first organocatalytic asymmetric reaction employing 3,4-dihydro-2-quinolone has been developed leading to the synthesis of biologically important 3,3-disubstituted-dihydro-2-quinolones. Cinchona alkaloid derived bifunctional amino-thiourea catalysts were found to be the best catalysts. The products were obtained in high enantio- and good diastereoselectivities and also few synthetic transformations have been demonstrated.

中文翻译：

3,3-二取代的3,4-二氢-2-喹诺酮类化合物的有机催化不对称合成

已经开发了使用3，4-二氢-2-喹诺酮的第一有机催化不对称反应，从而导致了生物学上重要的3，3-二取代-二氢-2-喹诺酮的合成。发现金鸡纳生物碱衍生的双官能氨基-硫脲催化剂是最好的催化剂。得到的产物具有高对映体和良好的非对映选择性，也已证明了很少的合成转化。

更新日期：2017-09-20

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