The first example of cobalt-catalyzed C(sp²)−H carbonylation of benzylamines using a traceless directing group is reported, which was successfully applied to the synthesis of N−unprotected iso-indolinones through direct C−H/N−H bonds activation. This protocol tolerates a variety of functional groups and provides a facile and efficient method for the formal synthesis of (+)-garenoxacin.

中文翻译：

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无痕导向基团辅助的钴催化苄胺的CH羰基化

报道了使用无痕导向基团钴催化苄胺的C（sp ²）-H羰基化的第一个实例，该实例已成功地用于通过直接CH / NH键活化的N-未保护的异吲哚啉酮的合成。该协议可以耐受各种功能基团，并提供了一种简便有效的方法来正式合成（+）-加仑沙星。