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Biocompatible and stable magnetosome minerals coated with poly-L-lysine, citric acid, oleic acid, and carboxy-methyl-dextran for application in the magnetic hyperthermia treatment of tumors
Journal of Materials Chemistry B ( IF 6.1 ) Pub Date : 2017-09-08 00:00:00 , DOI: 10.1039/c6tb03248f Chalani Mandawala 1, 2, 3, 4, 5 , Imène Chebbi 1, 2, 3 , Mickael Durand-Dubief 1, 2, 3 , Raphael Le Fèvre 1, 2, 3, 6, 7 , Yasmina Hamdous 1, 2, 3, 8, 9 , François Guyot 4, 5, 10, 11, 12 , Edouard Alphandéry 1, 2, 3, 4, 5
Journal of Materials Chemistry B ( IF 6.1 ) Pub Date : 2017-09-08 00:00:00 , DOI: 10.1039/c6tb03248f Chalani Mandawala 1, 2, 3, 4, 5 , Imène Chebbi 1, 2, 3 , Mickael Durand-Dubief 1, 2, 3 , Raphael Le Fèvre 1, 2, 3, 6, 7 , Yasmina Hamdous 1, 2, 3, 8, 9 , François Guyot 4, 5, 10, 11, 12 , Edouard Alphandéry 1, 2, 3, 4, 5
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Magnetic hyperthermia, in which magnetic nanoparticles are introduced into tumors and exposed to an alternating magnetic field (AMF), appears to be promising since it can lead to increased life expectancy in patients. Its efficacy can be further improved by using biocompatible iron oxide magnetosome minerals with better crystallinity and magnetic properties compared with chemically synthesized nanoparticles (IONP – Iron Oxide Nanoparticles). To fabricate such minerals, magnetosomes are first isolated from MSR-1 magnetotactic bacteria, purified to remove potentially toxic organic bacterial residues and stabilized with poly-L-lysine (N-PLL), citric acid (N-CA), oleic acid (N-OA), or carboxy-methyl-dextran (N-CMD). The different coated nanoparticles appear to be composed of a cubo-octahedral mineral core surrounded by a coating of different thickness, composition, and charge, and to be organized in chains of various lengths. The in vitro anti-tumor and heating efficacies of these nanoparticles were examined by bringing them into contact with GL-261 glioblastoma cells and by applying an AMF. This led to a specific absorption rate of 89–196 W gFe−1, measured using an AMF of 198 kHz and 34–47 mT, and to percentages of tumor cell destruction due to the exposure of the nanoparticles to the AMF of 10 ± 3% to 43 ± 3% depending on the coating agent. These results show the potential of this protocol for the tumor treatment by magnetic hyperthermia.
中文翻译：
具有生物相容性且稳定的磁小体矿物质，包被有聚L-赖氨酸，柠檬酸，油酸和羧甲基葡聚糖，可用于肿瘤的磁热疗
将磁性纳米颗粒引入肿瘤并暴露于交变磁场（AMF）的磁性热疗似乎很有希望，因为它可以延长患者的预期寿命。与化学合成的纳米粒子（IONP –氧化铁纳米粒子）相比，使用具有更好结晶性和磁性的生物相容性氧化铁磁小体矿物可以进一步提高其功效。为了制造此类矿物质，首先从MSR-1趋磁细菌中分离出磁小体，对其进行纯化以去除潜在的有毒有机细菌残留物，并用聚L稳定化。-赖氨酸（N-PLL），柠檬酸（N-CA），油酸（N-OA）或羧甲基-葡聚糖（N-CMD）。不同的涂层纳米颗粒似乎由一个立方八面体矿物核组成，周围被厚度，组成和电荷不同的涂层包围，并组织成各种长度的链。的体外抗肿瘤和这些纳米粒子的加热功效通过使它们与GL-261胶质瘤细胞接触并且通过施加AMF检查。这导致比吸收率为89–196 W g Fe -1，使用198 kHz的AMF和34-47 mT的AMF进行测量，以及由于纳米粒子暴露于AMF导致的肿瘤细胞破坏百分比为10±3％至43±3％（取决于涂层剂）。这些结果显示了该方案在通过磁热疗法治疗肿瘤中的潜力。
更新日期：2017-09-20
中文翻译：
具有生物相容性且稳定的磁小体矿物质，包被有聚L-赖氨酸，柠檬酸，油酸和羧甲基葡聚糖，可用于肿瘤的磁热疗
将磁性纳米颗粒引入肿瘤并暴露于交变磁场（AMF）的磁性热疗似乎很有希望，因为它可以延长患者的预期寿命。与化学合成的纳米粒子（IONP –氧化铁纳米粒子）相比，使用具有更好结晶性和磁性的生物相容性氧化铁磁小体矿物可以进一步提高其功效。为了制造此类矿物质，首先从MSR-1趋磁细菌中分离出磁小体，对其进行纯化以去除潜在的有毒有机细菌残留物，并用聚L稳定化。-赖氨酸（N-PLL），柠檬酸（N-CA），油酸（N-OA）或羧甲基-葡聚糖（N-CMD）。不同的涂层纳米颗粒似乎由一个立方八面体矿物核组成，周围被厚度，组成和电荷不同的涂层包围，并组织成各种长度的链。的体外抗肿瘤和这些纳米粒子的加热功效通过使它们与GL-261胶质瘤细胞接触并且通过施加AMF检查。这导致比吸收率为89–196 W g Fe -1，使用198 kHz的AMF和34-47 mT的AMF进行测量，以及由于纳米粒子暴露于AMF导致的肿瘤细胞破坏百分比为10±3％至43±3％（取决于涂层剂）。这些结果显示了该方案在通过磁热疗法治疗肿瘤中的潜力。
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