The improvement of corrosion resistance, biocompatibility and osteogenesis of the novel porous Mg–Nd–Zn alloy,Journal of Materials Chemistry B

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The improvement of corrosion resistance, biocompatibility and osteogenesis of the novel porous Mg–Nd–Zn alloy
Journal of Materials Chemistry B ( IF 6.1 ) Pub Date : 2017-08-23 00:00:00 , DOI: 10.1039/c7tb00920h
Wei Liu _{1,

2,

3,

4} , Jiaxing Wang _{1,

2,

3,

4} , Guofeng Jiang _{4,

5,

6,

7,

8} , Jinxiao Guo _{1,

2,

3,

4} , Qiuyan Li _{4,

5,

6,

7,

8} , Bin Li _{1,

2,

3,

4} , Qiaojie Wang _{1,

2,

3,

4} , Mengqi Cheng _{1,

2,

3,

4} , Guo He _{4,

5,

6,

7,

8} , Xianlong Zhang _{1,

2,

3,

4}

Affiliation

A magnesium scaffold is a promising biodegradable bone repair material. However, its poor corrosion resistance limits its clinical application. In this study, we improved the corrosion resistance, biocompatibility and osteointergration ability of magnesium by alloying it with neodymium (Nd) and zinc (Zn), then fabricated a novel open-porous Mg–Nd–Zn (P-MNZ) alloy using a titanium wire space holder (TWSH) method. An in vitro corrosion experiment showed that corrosion resistance was enhanced. Both in vitro and in vivo experiments were performed to evaluate the biocompatibility and osteointergration ability of P-MNZ. The cell viability, cytoskeleton staining, ALP activity and osteogenic related gene expression confirm that the P-MNZ scaffold exhibits better biocompatibility and osteoblast differentiation properties in vitro. As for the in vivo experiment, the analysis of micro-CT scanning, Van Gieson staining and sequential polychrome labelling demonstrated that P-MNZ stimulates new bone formation and enhances the corrosion resistance of the P-MNZ scaffold. The results indicate that the P-MNZ alloy is a promising biodegradable bone repair material.

中文翻译：

新型多孔Mg-Nd-Zn合金的耐蚀性，生物相容性和成骨性的提高

镁支架是一种有前途的可生物降解的骨修复材料。然而，其差的耐腐蚀性限制了其临床应用。在这项研究中，我们通过将镁与钕（Nd）和锌（Zn）合金化，提高了镁的耐腐蚀性，生物相容性和骨整合能力，然后使用一种新的开孔Mg–Nd–Zn（P-MNZ）合金制造了这种合金。钛丝空间保持器（TWSH）方法。的体外腐蚀试验结果表明，耐腐蚀性提高。二者在体外和体内进行实验以评估P-MNZ的生物相容性和骨整合能力。细胞活力，细胞骨架染色，ALP活性和成骨相关基因的表达证实了P-MNZ支架在体外具有更好的生物相容性和成骨细胞分化特性。至于体内实验，对微CT扫描，Van Gieson染色和顺序多色标记的分析表明，P-MNZ刺激了新的骨形成并增强了P-MNZ支架的耐腐蚀性。结果表明，P-MNZ合金是一种有前途的可生物降解的骨修复材料。

更新日期：2017-09-20

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