A facile preparation of a nanocomposite comprising FePt nanoparticles (NPs) and hollow mesoporous silica nanospheres (HMSNs) was reported. The bimetallic NPs had an alloy structure with Pt-rich cores and were highly dispersed on the mesoporous shell of HMSNs. The material, designated as FePt@MMT-2, could be gradually degraded and dissolved under physiological conditions and showed low cytotoxicity against HeLa cells. FePt@MMT-2 exhibited ferromagnetic-like properties and broadband near-infrared (NIR) absorption along with high photothermal transduction efficiency. In addition, in vitro studies showed high efficacy of FePt@MMT-2 in killing HeLa cells with 1064 nm NIR irradiation, and synergistic anticancer effects when combined with chemo drug topotecan. The results demonstrated the potential of the designed nanocomposite for theranostic applications.

中文翻译：

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空心介孔二氧化硅纳米球支撑的FePt纳米颗粒在潜在的治疗上的应用

报道了一种包含FePt纳米颗粒（NPs）和中空介孔二氧化硅纳米球（HMSNs）的纳米复合材料的简便制备方法。双金属NPs具有富Pt核的合金结构，并高度分散在HMSNs的介孔壳上。该材料命名为FePt @ MMT-2，可以在生理条件下逐渐降解和溶解，并且对HeLa细胞的细胞毒性较低。FePt @ MMT-2表现出类似铁磁的特性和宽带近红外（NIR）吸收以及高的光热转换效率。此外，体外研究表明，FePt @ MMT-2在用1064 nm NIR辐射杀死HeLa细胞方面具有很高的功效，并且当与化学药物拓扑替康联合使用时具有协同的抗癌作用。结果证明了所设计的纳米复合材料在诊断学应用中的潜力。