Hollow double-layered polymer nanoparticles with S-nitrosothiols for tumor targeted therapy,Journal of Materials Chemistry B

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Hollow double-layered polymer nanoparticles with S-nitrosothiols for tumor targeted therapy
Journal of Materials Chemistry B ( IF 6.1 ) Pub Date : 2017-08-17 00:00:00 , DOI: 10.1039/c7tb01715d
Tuanwei Liu _{1,

2,

3,

4,

5} , Jingjing Hu _{1,

2,

3,

4,

5} , Xiaoye Ma _{1,

2,

3,

4,

5} , Bing Kong _{6,

7,

8,

9} , Jilan Wang _{6,

8,

9,

10} , Zhide Zhang _{1,

2,

3,

4,

5} , Dian-Shun Guo _{1,

2,

3,

4,

5} , Xinlin Yang _{1,

11,

12,

13,

14}

Affiliation

College of Chemistry
Chemical Engineering and Materials Science
Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong
Key Laboratory of Molecular and Nano Probes
Ministry of Education, Shandong Normal University
Department of Anesthesiology
Shandong Maternal and Child Health Hospital
Jinan 250014
P. R. China
Shandong Provincal Hospital Affiliated to Shandong University
Key Laboratory of Functional Polymer Materials
Ministry of Education
Institute of Polymer Chemistry
Nankai University

Tumor targeted hollow double-layered polymer nanoparticles (HDPNs) with S-nitrosothiols for nitric oxide (NO)-release as chemotherapy were described. Via a two-stage distillation precipitation co-polymerization, simple post-treatment and S-nitrosothiol modification, the S-nitroso HDPNs showed pH and glucose dual responsiveness. This would benefit accurate binding with the sialic acid over-expressed cancer cells, providing prerequisites for the disulfide polymer assisted cell uptake, intracellular GSH induced decomposition and rapid NO release. Confocal microscopy and cytotoxicity assay with normal versus tumor cells demonstrated in vitro recognition, intracellular delivery ability and tumor cell targeting cytotoxicity. Especially worth mentioning, the inevitable small amount of NO leakage in the transmission would take part in normal physiological activities and not cause serious side effects, providing a possible solution to avoid the intolerable side effects of traditional chemotherapy treatments for cancer.

中文翻译：

带有S-亚硝基硫醇的空心双层聚合物纳米颗粒用于肿瘤靶向治疗

描述了带有S-亚硝基硫醇的一氧化氮（NO）释放的肿瘤靶向空心双层聚合物纳米粒子（HDPNs）作为化学疗法。通过两阶段蒸馏沉淀共聚合，简单后处理和s ^ -nitrosothiol变形例中，小号亚硝基HDPNs表明pH和葡萄糖双重响应性。这将有利于与过表达唾液酸的癌细胞的精确结合，为二硫化物聚合物辅助的细胞摄取，细胞内GSH诱导的分解和NO的快速释放提供了先决条件。正常与肿瘤细胞的共聚焦显微镜和细胞毒性测定在体外证明识别，细胞内传递能力和肿瘤细胞靶向细胞毒性。特别值得一提的是，传播途径中不可避免的少量NO泄漏会参与正常的生理活动，并且不会引起严重的副作用，这为避免传统化学疗法对癌症的不可忍受的副作用提供了可能的解决方案。

更新日期：2017-09-20

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