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Visualizing molecular distributions for biomaterials applications with mass spectrometry imaging: a review
Journal of Materials Chemistry B ( IF 6.1 ) Pub Date : 2017-08-11 00:00:00 , DOI: 10.1039/c7tb01100h Martin R. L. Paine 1, 2, 3, 4, 5 , Pieter C. Kooijman 1, 2, 3, 4, 6 , Gregory L. Fisher 7, 8, 9 , Ron M. A. Heeren 1, 2, 3, 4 , Facundo M. Fernández 5, 9, 10, 11, 12 , Shane R. Ellis 1, 2, 3, 4
Journal of Materials Chemistry B ( IF 6.1 ) Pub Date : 2017-08-11 00:00:00 , DOI: 10.1039/c7tb01100h Martin R. L. Paine 1, 2, 3, 4, 5 , Pieter C. Kooijman 1, 2, 3, 4, 6 , Gregory L. Fisher 7, 8, 9 , Ron M. A. Heeren 1, 2, 3, 4 , Facundo M. Fernández 5, 9, 10, 11, 12 , Shane R. Ellis 1, 2, 3, 4
Affiliation
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Mass spectrometry imaging (MSI) is a rapidly emerging field that is continually finding applications in new and exciting areas. The ability of MSI to measure the spatial distribution of molecules at or near the surface of complex substrates makes it an ideal candidate for many applications, including those in the sphere of materials chemistry. Continual development and optimization of both ionization sources and analyzer technologies have resulted in a wide array of MSI tools available, both commercially available and custom-built, with each configuration possessing inherent strengths and limitations. Despite the unique potential of MSI over other chemical imaging methods, their potential and application to (bio)materials science remains in our view a largely underexplored avenue. This review will discuss these techniques enabling high parallel molecular detection, focusing on those with reported uses in (bio)materials chemistry applications and highlighted with select applications. Different technologies are presented in three main sections; secondary ion mass spectrometry (SIMS) imaging, matrix-assisted laser desorption ionization (MALDI) MSI, and emerging MSI technologies with potential for biomaterial analysis. The first two sections (SIMS and MALDI) discuss well-established methods that are continually evolving both in technological advancements and in experimental versatility. In the third section, relatively new and versatile technologies capable of performing measurements under ambient conditions will be introduced, with reported applications in materials chemistry or potential applications discussed. The aim of this review is to provide a concise resource for those interested in utilizing MSI for applications such as biomimetic materials, biological/synthetic material interfaces, polymer formulation and bulk property characterization, as well as the spatial and chemical distributions of nanoparticles, or any other molecular imaging application requiring broad chemical speciation.
中文翻译：
通过质谱成像可视化生物材料应用中的分子分布：综述
质谱成像（MSI）是一个快速发展的领域，正在不断地在新的激动人心的领域中找到应用。MSI能够测量复杂基材表面处或附近分子的空间分布，使其成为许多应用（包括材料化学领域中的应用）的理想候选者。电离源和分析仪技术的不断发展和优化，导致产生了各种各样的MSI工具，无论是市售的还是定制的，每种配置都具有固有的优势和局限性。尽管MSI相对于其他化学成像方法具有独特的潜力，但在我们看来，它们的潜力和在（生物）材料科学中的应用仍处于很大程度上未开发的途径。这篇综述将讨论实现高度并行分子检测的这些技术，重点关注在（生物）材料化学应用中已报道用途的技术，并重点介绍某些应用。三个主要部分介绍了不同的技术。二次离子质谱（SIMS）成像，基质辅助激光解吸电离（MALDI）MSI和新兴的具有生物材料分析潜力的MSI技术。前两个部分（SIMS和MALDI）讨论了行之有效的方法，这些方法在技术进步和实验多功能性方面都在不断发展。在第三部分中，将介绍能够在环境条件下进行测量的相对较新的通用技术，并讨论在材料化学或潜在应用中的报道应用。
更新日期：2017-09-20
中文翻译：
通过质谱成像可视化生物材料应用中的分子分布：综述
质谱成像（MSI）是一个快速发展的领域，正在不断地在新的激动人心的领域中找到应用。MSI能够测量复杂基材表面处或附近分子的空间分布，使其成为许多应用（包括材料化学领域中的应用）的理想候选者。电离源和分析仪技术的不断发展和优化，导致产生了各种各样的MSI工具，无论是市售的还是定制的，每种配置都具有固有的优势和局限性。尽管MSI相对于其他化学成像方法具有独特的潜力，但在我们看来，它们的潜力和在（生物）材料科学中的应用仍处于很大程度上未开发的途径。这篇综述将讨论实现高度并行分子检测的这些技术，重点关注在（生物）材料化学应用中已报道用途的技术，并重点介绍某些应用。三个主要部分介绍了不同的技术。二次离子质谱（SIMS）成像，基质辅助激光解吸电离（MALDI）MSI和新兴的具有生物材料分析潜力的MSI技术。前两个部分（SIMS和MALDI）讨论了行之有效的方法，这些方法在技术进步和实验多功能性方面都在不断发展。在第三部分中，将介绍能够在环境条件下进行测量的相对较新的通用技术，并讨论在材料化学或潜在应用中的报道应用。
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