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Copper-catalysed difluoroalkylation of aromatic aldehydes via a decarboxylation/aldol reaction
Organic & Biomolecular Chemistry ( IF 2.9 ) Pub Date : 2017-08-29 00:00:00 , DOI: 10.1039/c7ob01739a
Jin-Wei Yuan 1, 2, 3, 4 , Shuai-Nan Liu 1, 2, 3, 4 , Wen-Peng Mai 1, 2, 3, 4
Affiliation  

A copper-catalysed tandem decarboxylation/aldol reaction of simple aromatic aldehydes with 2,2-difluoro-3-oxo-3-arylpropanoic acid has been developed under mild conditions. This method provides a new route for the direct one-pot synthesis of difluorinated aldols in moderate to good yields from simple substrates.

中文翻译:

通过脱羧/羟醛反应催化芳香醛的二氟烷基化

在温和条件下,已开发出铜催化的简单芳香族醛与2,2-二氟-3-氧代-3-芳基丙酸的串联脱羧/羟醛反应。该方法提供了一种从简单底物以中等到良好产率直接一锅合成二氟羟醛醇的新途径。
更新日期:2017-09-20
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