Copper-catalysed difluoroalkylation of aromatic aldehydes via a decarboxylation/aldol reaction,Organic & Biomolecular Chemistry

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Copper-catalysed difluoroalkylation of aromatic aldehydes via a decarboxylation/aldol reaction
Organic & Biomolecular Chemistry ( IF 2.9 ) Pub Date : 2017-08-29 00:00:00 , DOI: 10.1039/c7ob01739a
Jin-Wei Yuan _{1,

2,

3,

4} , Shuai-Nan Liu _{1,

2,

3,

4} , Wen-Peng Mai _{1,

2,

3,

4}

Affiliation

A copper-catalysed tandem decarboxylation/aldol reaction of simple aromatic aldehydes with 2,2-difluoro-3-oxo-3-arylpropanoic acid has been developed under mild conditions. This method provides a new route for the direct one-pot synthesis of difluorinated aldols in moderate to good yields from simple substrates.

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