Oxidative C–H functionalization of N-carbamoyl 1,2-dihydroquinolines,Organic & Biomolecular Chemistry

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Oxidative C–H functionalization of N-carbamoyl 1,2-dihydroquinolines
Organic & Biomolecular Chemistry ( IF 2.9 ) Pub Date : 2017-08-25 00:00:00 , DOI: 10.1039/c7ob01793f
Ziqiang Liu _{1,

2,

3,

4,

5} , Lei Chen _{3,

6,

7,

8} , Jing Li _{3,

9,

10,

11} , Ke Liu _{3,

9,

10,

11} , Jiaqi Zhao _{3,

9,

10,

11} , Mengmeng Xu _{3,

9,

10,

11} , Lei Feng _{3,

9,

10,

11} , Ren-zhong Wan _{3,

6,

7,

8} , Wei Li _{3,

4,

5,

12,

13} , Lei Liu _{1,

2,

3,

9,

10}

Affiliation

A modular and efficient method for the synthesis of α-substituted 1,2-dihydroquinolines is described. Under mild metal-free conditions, readily available N-carbamoyl 1,2-dihydroquinolines undergo oxidative C–H alkynylation, alkenylation, and allylation with a range of potassium trifluoroborates using TEMPO oxoammonium salt as an oxidant.

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