Conformational mobility is a core property of organic compounds, and conformational analysis has become a pervasive tool for synthetic design. In this work, we present experimental and computational (employing Density Functional Theory) evidence for unusual intramolecular hydrogen bonding interactions in a series of α-acylmethane derivatives, as well as a discussion of the consequences thereof for their NMR spectroscopic properties.

中文翻译：

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构象半刚性α-酰基甲烷衍生物中的分子内氢键：理论NMR研究

构象迁移是有机化合物的核心特性，构象分析已成为合成设计的普遍工具。在这项工作中，我们提供了一系列α-酰基甲烷衍生物中异常分子内氢键相互作用的实验和计算证据（采用密度泛函理论），并讨论了其对NMR光谱性质的影响。