Mapping the interaction sites of Mucin 1 and DNA aptamer by atomic force microscopy,Analyst

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Mapping the interaction sites of Mucin 1 and DNA aptamer by atomic force microscopy
Analyst ( IF 3.6 ) Pub Date : 2017-09-01 00:00:00 , DOI: 10.1039/c7an01119a
Nan Wang _{1,

2,

3,

4,

5} , Miaomiao Zhang _{1,

2,

3,

4,

5} , Xuejuan Chen _{1,

2,

3,

4,

5} , Xingxing Ma _{1,

2,

3,

4,

5} , Chen Li _{1,

2,

3,

4,

5} , Zhe Zhang _{1,

2,

3,

4,

5} , Jilin Tang _{1,

2,

3,

4,

5}

Affiliation

Mucin 1 (MUC1) is an attractive tumor marker for cancer diagnosis. An advanced atomic force microscopy (AFM) mode, peak-force tapping AFM with an aptamer functionalized tip, was introduced to map the specific interaction sites of an aptamer and MUC1. Single molecular force spectroscopy (SMFS) was used to investigate dynamic parameters of the aptamer–MUC1.

中文翻译：

通过原子力显微镜绘制Mucin 1和DNA适体的相互作用位点

粘蛋白1（MUC1）是用于癌症诊断的有吸引力的肿瘤标志物。引入了先进的原子力显微镜（AFM）模式，即带有适体功能化尖端的峰值力攻丝AFM，以绘制适体和MUC1的特定相互作用位点。单分子力谱（SMFS）用于研究适体–MUC1的动力学参数。

更新日期：2017-09-20

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